What are atheroma and cardiovascular diseases?
Patches of atheroma are like small fatty lumps that develop within the inside lining of arteries (blood vessels). Atheroma is also known as 'atherosclerosis' and 'hardening of the arteries'. Patches of atheroma are often called 'plaques' of atheroma.
Over months or years, patches of atheroma can become larger and thicker. So, in time, a patch of atheroma can make an artery narrower. This can reduce the blood flow through the artery. For example, narrowing of the coronary (heart) arteries with atheroma is the cause of angina.
Sometimes, a blood clot (thrombosis) forms over a patch of atheroma and completely blocks the blood flow. Depending on the artery affected, this can cause a heart attack, a stroke, or other serious problems.
Cardiovascular diseases are diseases of the heart (cardiac muscle) or blood vessels (vasculature). However, in practice, when doctors use the term 'cardiovascular disease' they usually mean diseases of the heart or blood vessels that are caused by atheroma.
In summary, cardiovascular diseases that can be caused by atheroma include: angina, heart attack, stroke, transient ischaemic attack (TIA), and peripheral vascular disease. In the UK, cardiovascular diseases are a major cause of poor health, and the biggest cause of death.
What factors affect the blood level of cholesterol?
In most people, your cholesterol level reflects the amount of fat that you eat. This is not the full story as different people who eat the same amount of fat can make different amounts of cholesterol. However, in general, if you eat less fat your cholesterol level is likely to go down.
In some people, a high cholesterol level is due to another condition. For example, an under active thyroid gland, obesity, drinking a lot of alcohol, and some rare kidney and liver disorders can raise the cholesterol level.
In some people, a very high level of cholesterol runs in the family due to an inherited genetic problem with the way cholesterol is made. One example is called familial hypercholesterolaemia.
Everybody has some risk of developing atheroma which then may cause one or more cardiovascular diseases. However, certain 'risk factors' increase the risk. Risk factors include:
Lifestyle risk factors that can be prevented or changed:
o Lack of physical activity (a sedentary lifestyle).
o An unhealthy diet - including eating too much salt.
o Excess alcohol.
Treatable or partly treatable risk factors:
o Hypertension (high blood pressure).
o High cholesterol blood level.
o High trigliceride (fat) blood level.
o Kidney diseases that affect kidney function.
Fixed risk factors - ones that you cannot alter:
o A strong family history. This means if you have a father or brother who developed heart disease or a stroke before they were 55, or in a mother or sister before they were 65.
o Being male.
o An early menopause in women.
o Age. The older you become, the more likely you are to develop atheroma.
o Ethnic group. For example, people who live in the UK with ancestry from India, Pakistan, Bangladesh, or Sri Lanka have an increased risk.
However, if you have a fixed risk factor, you may want to make extra effort to tackle any lifestyle risk factors that can be changed.
Note: some risk factors are more 'risky' than others. For example, smoking and a high cholesterol level probably cause a greater risk to health than obesity. Also, risk factors interact. So, if you have two or more risk factors, your health risk is much more increased than if you just have one. For example, a middle aged male smoker who has high blood pressure and a high cholesterol level has a high risk of developing a cardiovascular disease such as a heart attack before the age of 60.
What is a 'high' cholesterol level?
The following levels are generally regarded as desirable:
As a rule, the higher the cholesterol level, the greater the risk to health.
However, your level of cholesterol has to be viewed as part of your overall cardiovascular health risk. The cardiovascular health risk from any given level of cholesterol can vary, depending on the level of your HDL cholesterol, and on other health risk factors that you may have.
Assessing (calculating) your cardiovascular health risk
A 'risk factor calculator' is commonly used by doctors and nurses. This can assess your cardiovascular health risk. A score is calculated which takes into account all your risk factors such as age, sex, smoking status, blood pressure, cholesterol level, etc.
The calculator has been devised after a lot of research that monitored thousands of people over a number of years. The score gives a fairly accurate indication of your risk of developing a cardiovascular disease over the next 10 years. If you want to know your 'score', see your practice nurse or GP.
Who should have their cardiovascular health risk assessed?
Current UK guidelines advise that the following people should be assessed to find their cardiovascular health risk:
All adults aged 40 or more.
o A strong family history of early cardiovascular disease. This means if you have a father or brother who developed heart disease or a stroke before they were 55, or in a mother or sister before they were 65.
o A first degree relative (parent, brother, sister, child) with a serious hereditary lipid disorder. For example, familial hypercholesterolaemia or familial combined hyperlipidaemia. These diseases are uncommon.
If you already have a cardiovascular disease or diabetes then your risk does not need to be assessed. This is because you are already known to be in the high risk group.
What does the assessment involve?
A doctor or nurse will:
A score is calculated based on these factors plus your age and your sex. An adjustment to the score is made for certain other factors such as strong family history and ethnic origin.
What does the assessment score mean?
You are given a score as a % chance. So, for example, if your score is 30% this means that you have a 30% chance of developing a cardiovascular disease within the next 10 years. This is the same as saying a 30 in 100 chance (or a 3 in 10 chance). In other words, in this example, 3 in 10 people with the same score that you have will develop a cardiovascular disease within the next 10 years. Note: the score cannot say if you will be one of the three. It cannot predict what will happen to each individual person. It just gives you the odds.
You are said to have a:
Who should be treated to reduce their cardiovascular health risk?
Treatment to reduce the risk of developing a cardiovascular disease is usually offered to people with a high risk. That is:
The following people should also have drug treatment to lower their cholesterol level, regardless of any calculated risk. The risk calculator may not necessarily take these people into account who have a high risk of developing atheroma.
What treatments are available to reduce the risk?
If you are at high risk of developing a cardiovascular disease then drug treatment is usually advised along with advice to tackle any lifestyle issues. This usually means:
Whichever is the biggest reduction.
If available, and if required, you may be offered a referral to a specialist service. For example, to a dietician to help you to lose weight and eat a healthy diet, to a specialist 'stop smoking clinic', or to a supervised exercise programme.
Can diet lower my cholesterol level?
Changing from an unhealthy diet to a healthy diet can reduce a cholesterol level. However, dietary changes alone rarely lower a cholesterol level enough to change a person's risk of cardiovascular disease from a high risk category to a lower risk. However, any extra reduction in cholesterol due to diet will help. A healthy diet has other benefits too apart from reducing the level of cholesterol.
Briefly, a healthy diet means:
In addition, foods that contain plant sterols or stanols can reduce blood cholesterol level. For example, a daily dose of about 2 g of plant sterols or stanols can reduce LDL cholesterol by about 10%. Plant sterols and stanols are available in margarine spreads, yoghurts, milk drinks and other foods sold in stores. Food products containing plant sterols and stanols are generally designed to provide about one third of the recommended daily dose per meal. However, always read the labels and follow the manufacturer's advice about portion sizes. Recommendations from the Food Standards Agency include the following:
How much benefit do I get if my cholesterol level is reduced?
If you have an increased risk of developing an atheroma related disease, your risk can be reduced by up to 30% if your cholesterol level is lowered to a target level.
If you already have an atheroma related disease, lowering the cholesterol level reduces your risk of further problems.
What if I am at moderate or low risk?
If you are not in the high risk category, it does not mean you have no risk - just a lesser risk. Drug treatment is not usually prescribed. However, you may be able to reduce whatever risk you do have even further by any relevant changes in lifestyle (as described above).
Some people with a moderate risk buy a low dose statin drug from a pharmacy to lower their cholesterol level. (Statin drugs are available on prescription and funded by the NHS if your risk is high. However, you need to buy them if your risk is not in the high category. But, if you do buy a statin and take it regularly, it is best to let you doctor know so that it can be put on your medical record.)
Dr Annebirthe Bo Hansen, Professor Ian Campbell, NetDoctor, Patient UK, Heart UK, British Heart Foundation, British Nutrition Foundation.