Epiduo 0.1%/2.5% Gel

Buy Epiduo Gel for Acne

Epiduo is a combination treatment that contains both the retinoid adapalene and the peeling agent benzoyl peroxide. It is used for the treatment of acne. It may be recommended if Differin was unsuccessful after 8 weeks of use.

All our products are genuine UK medicines and are dispensed by our partner pharmacy based in the UK.

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  • Combination treatment containing topical retinoid and peeling agent
  • Contains the active ingredients adapalene and benzoyl peroxide
  • To be considered if single treatments (Differin or Zineryt) have not worked
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Epiduo Gel combines two active ingredients, adapalene and benzoyl peroxide, which work together but in different ways. Adapalene belongs to a group of products known as retinoids and acts specifically on the skin processes that cause acne. The other active ingredient, benzoyl peroxide, works as an antimicrobial agent and by softening and peeling the outer layer of the skin.


Do not use Epiduo Gel if you are allergic (hypersensitive) to adapalene, benzoyl peroxide or any of the other ingredients listed in the patient information leaflet.

Pregnancy and Breastfeeding

Epiduo should not be used during pregnancy. Epiduo can be used during breastfeeding. To avoid contact exposure of the infant, application of Epiduo to the chest must be avoided. Always ask your doctor or pharmacist for advice before taking any medicine.

Important Interactions

You must tell your doctor if you are taking, have recently taken or might take other medicines, in particular:

  • other acne products (containing benzoyl peroxide and / or retinoids) at the same time as Epiduo
  • at the same time as cosmetics that are irritant, drying or exfoliate the skin
Side Effects
  • dry skin
  • local skin rash (irritative contact dermatitis)
  • burning sensation
  • irritation of the skin
  • redness
  • scaling
Please Note

All medication can cause side effects. We have only listed a few to be aware of. Details of all side effects, including rare side effects to be aware of, are listed in the patient information leaflet (PIL). When completing your medical questionnaire, it is very important that you answer the questions truthfully. This is to ensure your doctor has a full picture of your medical history before prescribing. List all medicines you are already taking, including non-prescription and herbal medicines.


Further products available include Zineryt (topical antibiotic), Differin (topical retinoid) and Skinoren (azelaic acid). Duac Once Daily is another combination treatment available including benzoyl peroxide plus a topical antibiotic.

Other treatments for more severe acne are also available such as Roaccutane (isotretinoin) and Dianette (a contraceptive pill for women only). These treatments need to be monitored closely and can only be prescribed by your GP or specialist dermatologist.

Looking after your medicine

Do not take medicines after the expiry date stamped on the pack. Keep all medicines out of the reach and sight of children.

Medicines are only intended to be used by the person they are prescribed for. Do not give your prescribed medicine to anybody else, even if they have the same symptoms as you. Medicines can be harmful if used by anybody other than the person they have been prescribed for.

References Epiduo 0.1%/2.5% Gel Patient Information Leaflet
British National Formulary: adapalene with benzoyl peroxide
Last reviewed & updated  14/02/2020   Authored  24/01/2010

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  4. 4

    Medicine delivered the next day