Spedra 50mg, 100mg, 200mg

Spedra contains the active substance avanafil. It belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors. Spedra is a treatment for men who cannot get, or keep a hard, erect penis suitable for sexual activity.

Do not take Spedra:

• if you are allergic (hypersensitive) to avanafil or any of the other ingredients listed in the patient information leaflet
• if you are taking nitrate medicines for chest pain (angina), such as amyl nitrite or glyceryl trinitrate
• if you are taking medicines for HIV or AIDS such as ritonavir, indinavir, saquinavir, nelfinavir or atazanavir
• if you are taking medicines for fungal infections such as ketoconazole, itraconazole or voriconazole or certain antibiotics for bacterial infections, such as clarithromycin or telithromycin
• if you have a serious cardiac problem
• if you have had a stroke or heart attack in the last 6 months
• if you have low blood pressure or high blood pressure not controlled by medicines
• if you have chest pain (angina) or you get chest pain during sexual intercourse
• if you have a serious liver or kidney problem
• if you have loss of vision in one eye due to not enough blood getting to your eye (non-arteritic ischemic optic neuropathy - NAION)
• if certain serious eye problems run in your family (such as retinitis pigmentosa)
• if you are taking riociguat - used to treat pulmonary arterial hypertension (i.e. high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (i.e. high blood pressure in the lungs secondary to blood clots)

Spedra is not to be used by women

You must tell your doctor if you are taking, have recently taken or might take other medicines, in particular:

• alpha-blockers – for prostate problems or for lowering your high blood pressure
• medicines for an irregular heartbeat (arrhythmia) such as quinidine, procainamide, amiodarone or sotalol
• antibiotics for infections such as erythromycin
• phenobarbital or primidone – for epilepsy
• carbamazepine – for epilepsy, to stabilise your mood or for certain types of pain
• other medicines that may reduce the breakdown of Spedra in the body (moderate CYP3A4 inhibitors) including amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, and verapamil
• riociguat

• headache
• flushing
• nasal congestion

Other ED medications include Viagra (Sildenafil), Cialis and Levitra. Alternative treatments to ED medication include treating underlying physical or psychological causes, undergoing lifestyle changes, vacuum devices and surgical intervention.