Differin 0.1% w/w Cream and Gel

Buy Differin (Cream or Gel) for Acne

Differin is a topical retinoid and contains the active ingredient adapalene. This is good for unblocking pores which can cause spots.

All our products are genuine UK medicines and are dispensed by our partner pharmacy based in the UK.

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  • Topical retinoid
  • Contains the active ingredient adapalene
  • Available as a gel or cream
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The active ingredient in Differin is the topical retinoid adapalene, which has an anti-inflammatory effect and reduces soreness and irritation. It is used on the face, chest or back for acne, where the skin has a lot of blackheads, spots and pimples. Differin is only absorbed into the body in very small amounts and has little effect, except on the surface of the skin.


Do not use Differin (Cream or Gel):

  • if you are allergic (hypersensitive) to adapalene or any of the other ingredients listed in the patient information leaflet
  • if you are pregnant
  • if you are planning a pregnancy
  • on areas where you have cuts or scrapes or if you have a skin condition called eczema

Pregnancy and Breastfeeding
  • DO NOT use Differin if you are pregnant or thinking of becoming pregnant
  • If you fall pregnant while using Differin, the treatment must be discontinued and you should inform your doctor as soon as possible for a further follow-up.
  • Differin can be used during breastfeeding - to avoid contact exposure of the infant, application of Differin to the chest should be avoided
Important Interactions

You must tell your doctor if you are taking, have recently taken or might take other medicines, in particular other acne products containing benzoyl peroxide, erythromycin or clindamycin. These may be used with Differin, but they MUST be applied in the morning and Differin at night.

Side Effects
  • dry skin
  • irritation of the skin
  • burning sensation of the skin
  • redness of the skin (erythema)
  • local skin reaction (contact dermatitis)
  • peeling skin (exfoliation)
Please Note

All medication can cause side effects. We have only listed a few to be aware of. Details of all side effects, including rare side effects to be aware of, are listed in the patient information leaflet (PIL). When completing your medical questionnaire, it is very important that you answer the questions truthfully. This is to ensure your doctor has a full picture of your medical history before prescribing. List all medicines you are already taking, including non-prescription and herbal medicines.


Further products available include Zineryt (topical antibiotic) and Skinoren (azelaic acid). Combination treatment Duac Once Daily (with topical antibiotic plus benzoyl peroxide) or Epiduo (with topical retinoid plus benzoyl peroxide) are available to step up to if other treatments have not been successful.

Other treatments for more severe acne are also available such as Roaccutane (isotretinoin) and Dianette (a contraceptive pill for women only). These treatments need to be monitored closely and can only be prescribed by your GP or specialist dermatologist.

Looking after your medicine

Do not take medicines after the expiry date stamped on the pack. Keep all medicines out of the reach and sight of children.

Medicines are only intended to be used by the person they are prescribed for. Do not give your prescribed medicine to anybody else, even if they have the same symptoms as you. Medicines can be harmful if used by anybody other than the person they have been prescribed for.

References Differin 0.1% w/w Cream Patient Information Leaflet
Differin 0.1% w/w Gel Patient Information Leaflet
British National Formulary: adapalene
Last reviewed & updated  14/02/2020   Authored  24/01/2010

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