Atovaquone/Proguanil Hydrochloride 250mg/100mg

Buy Atovaquone/Proguanil Hydrochloride for Anti-Malaria Treatment

Atovaquone/Proguanil Hydrochloride is the generic version of the branded anti-malarial medication Malarone. It contains the same two active ingredients (atovaquone and proguanil hydrochloride) as Malarone. It is effective in most areas of the world and generally well tolerated. Tablets are only continued for one week after leaving a malaria region.

All our products are genuine UK medicines and are dispensed by our partner pharmacy based in the UK.

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  • Generic version of the brand medication Malarone
  • Effective in most areas of the world and generally well tolerated
  • Needs to be taken for 1 week after leaving a malaria area
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Atovaquone/Proguanil Hydrochloride belongs to a group of medicines called antimalarials. It contains two active ingredients, atovaquone and proguanil hydrochloride. Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (Plasmodium falciparum) into the bloodstream. Atovaquone/Proguanil Hydrochloride prevents malaria by killing this parasite.


Do not take Atovaquone/Proguanil Hydrochloride:

  • if you are allergic (hypersensitive) to atovaquone or proguanil hydrochloride or any of the other ingredients listed in the patient information leaflet
  • if you have severe kidney disease
Pregnancy and Breastfeeding

If you are pregnant, do not take Atovaquone/Proguanil Hydrochloride unless your doctor recommends it. Do not breastfeed while taking Atovaquone/Proguanil Hydrochloride, as the ingredients of Atovaquone/Proguanil Hydrochloride may pass into breast milk and may harm your baby.

Important Interactions

You must tell your doctor if you are taking, have recently taken or might take other medicines, in particular:

  • metoclopramide, used to treat nausea and vomiting
  • the antibiotics, tetracycline, rifampicin and rifabutin
  • efavirenz or certain highly active protease-inhibitors used to treat HIV
  • warfarin and other medicines that stop blood clotting
  • etoposide used to treat cancer
Side Effects
  • headache
  • feeling sick and being sick (nausea and vomiting)
  • stomach pain
  • diarrhoea
Please Note

All medication can cause side effects. We have only listed a few to be aware of. Details of all side effects, including rare side effects to be aware of, are listed in the patient information leaflet (PIL). When completing your medical questionnaire, it is very important that you answer the questions truthfully. This is to ensure your doctor has a full picture of your medical history before prescribing. List all medicines you are already taking, including non-prescription and herbal medicines.


The right anti-malarial you require will depend on where you are travelling to. Anytime Doctor also provides branded Malarone and Doxycycline. Other anti-malarial medicines include chloroquine (also known as Avloclor tablets or Nivaquine syrup) and proguanil (also known as Paludrine). The major disadvantage of these two medicines is that many strains of malaria are now resistant, so the drugs are no longer effective. We therefore do not offer chloroquine and proguanil alone. We also do not offer Lariam (mefloquine).

Looking after your medicine

Do not take medicines after the expiry date stamped on the pack. Keep all medicines out of the reach and sight of children.

Medicines are only intended to be used by the person they are prescribed for. Do not give your prescribed medicine to anybody else, even if they have the same symptoms as you. Medicines can be harmful if used by anybody other than the person they have been prescribed for.

References Atovaquone/Proguanil Hydrochloride 250mg/100mg Patient Information Leaflet
British National Formulary: atovaquone with proguanil hydrochloride

Please see the following table for the usual recommendations for using Atovaquone/Proguanil Hydrochloride for malaria prevention:

  • 1 week trip: 16 tablets
  • 2 week trip: 23 tablets
  • 3 week trip: 30 tablets
  • 4 week trip: 37 tablets
  • 8 week trip: 65 tablets
  • 12 week trip: 93 tablets

We can provide Atovaquone/Proguanil Hydrochloride tablets for antimalarial protection for other trip durations. Please inform your doctor during your consultation, who will be happy to advise you further.

It is usually recommended that you start taking Atovaquone/Proguanil Hydrochloride 2 days before entering a malaria area. Please always read the patient information leaflet and follow the prescribing advice provided by your doctor.

You will usually be required to take Atovaquone/Proguanil Hydrochloride for 1 week after leaving the malaria area. Please follow the prescribing instructions that come with your medicine.

Last reviewed & updated  25/03/2020   Authored  06/09/2010

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