Isotretinoin  has been a dramatically successful treatment therapy for severe and persistent Acne. Initially it was only used for sever cystic acne, its use has been gradually extended for those with significant but milder acne that will not clear despite persistent use of conventional topical and oral therapies. Isotretinoin has an important role in those with scarring because of their Acne. Most studies indicate a success rate of almost 100% and confirm that approximately two-thirds of patients have no relapse when treatment is discontinued. However, it is not clear whether these figures are correct for the patient types now being treated with Isotretinoin.

The potential side effects of Isotretinoin have been well documented and the need for appropriate care in its use, particularly in women at risk of pregnancy is well understood. More recent concerns over the unconfirmed development of mood changes and particularly depression have led to further caution.

Dosage Regimes: Most patients will be treated with dosages between 0.5 and 1.0 mg/kg bodyweight. Data indicate that while side-effects may be lessened by lower dosage regimes, the chance of relapse is higher. Generally treatment lasts for 16 weeks. Isotretinoin is contraindicated in patients with hyper vitaminosis A, uncontrolled hyperlipidaemia, and during pregnancy or lactation. It should also be used with caution in patients with renal and liver disease.

Tags :   Acne